Flexure can be one of those really nasty things to overcome, I don't know how much shift you have but considering a pixel can be 5-9 microns it doesn't take much.
If all your mounting points are rock solid, you still have other points, Rigidity of the focuser, particularly if extensions are used, down to the tightness of any compression rings etc..... ANY point of potential movement MUST be checked.
I had a 12 inch newt and it drove me nuts.
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