Hi Bill,
Certainly lose the barlow for alignment, adding it later won't change it. You could use a different scope if you like, as long as you don't physically move the mount itself after it's complete. Or use the guide scope for PA as you suggest. Being able to use the guide scope as an electronic finder scope is also an advantage going that way. Or you could go the old fashion way & learn how to drift align...
Note that with plate solving it can also depend on the database you're using as to whether you get a result or not. As the focal length increases, the field of view reduces so you need a database with more stars per square degree to get a result. I use ASTAP with it's larger D80 database to cover longer focal lengths.
Cheers,
Mark