I have tried external guide, self guide, OAGing and Ao at long FLs.
Each of these have advantages and show stoping disadvantages.
External guide is by far the most convienient and worth pursuing to the nth degree before before even thinking about the rest IMO. But the longer the FL, say over 2m the more you are forced to consider alternatives, but the much harder they get to use.
External guide allows composition of the target anyway you want, and you always get a guide star, point and go, but flexure just gets too much of a problem with exposures over 20min at over 2m FL.
SBIG internal guide is essentially impossible through NB filters unless you have a very stable mount with very low PE (eg a PME) that can get away with guide exposures of say 30secs or more, even RGB is difficult. And finding a bright guide star can be a very frustrating excerise, making composition tricky too.
Forget AO with internal guide unless useing just a lum filter (or none). AO is generally only of value if guide exposures can be 2 secs or less, otherwise there is no advantage over normal mount correction.
With internal and OAGing, manually rotating to find a bright guide star at long FLs is a painfull excercise, very hit and miss, and you have to wait till the rig settles down after bumping it, although as Alex mentions with OAG, widefield is less of a problem and a guide star maybe available without much or any rotation.
For OAG, I decided to use an autorotator for guide star searching, and that makes a huge difference, I can nudge and expose in quick succession with no disturbance.
I tried the rotator/TCFs focuser/MOAG/AO8/filter/ST10 on a 12" LX and found a showstoping problem I didnt think was going to be that bad untill I tried it. The image train is 350mm, the LX can focus, but stars are huge blobs

. I dont know why yet, but I cant see anyway to make this work unless I make the train shorter. Perhaps removing the AO8 will help, but the focuser and OAGer(MOAG) are the longest items (and many adaptors), I cant get rid of them, that would defeat OAG. The rotator cant go iether IMO.
So if anyone is considering OAG on a SCT, youd need to be very sure the back focus distance can take it. Just the OAG, filter and cam would be OK, but at long FLs, not haveing a autofocuser and autorotator would be a pain in the butt IMO.
I fitted all the above to an RCOS (minus the focuser), shaved .2" off an adaptor, and it just perfectly hits BFD, no spacers, shear luck

. It all works very well, each item making the whole worth while.