Hi,
Another factor apart from the size is also the quality of the scope and what your prepared to put up with. The 12" lightbridge appears to be without its own minor problems and by all accounts easy to fix (eg, new springs, collimation knobs etc). I would assume the 16" LB would be the same - one would hope Meade sorted these issues out.

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If on the other hand you want say the best and money is not an issue, it would be hard not to consider an SDM truss dob. Sure your paying a lot more, but then again your getting an absolute premium product. One that will most likely require no mods or changes at all and something that your likely to keep forever.
NB: I'm not bagging the LB, none the least, the 12" LB is a beauty and its the one I'd get. The 16" on the otherhand is yet to be 'road tested' and it would be interesting to see how it goes.
Good luck with your decision!