Greg,
In the largest (cropped) version of your image, I seem to see an enhanced density of compact blue sources (clusters?) (blue knots?) surrounding the bright portions of M83
What do you think?
M83 is thought to have some very luminous and massive young star clusters in it; more massive than any in the Milky Way.
In addition, in the ultraviolet, it is very obvious that there are many Ultraviolet-emitting knots stretching a long way outwards from the obvious portions of this galaxy.
Here is the GALEX image showing these UV/blue knots, which are very luminous in the UV:

If you go to
http://galex.stsci.edu/GalexView and search for ultraviolet images of M83 (making sure to pick the longest exposure image of this galaxy) you can see these UV knots in greater detail. They extend away from M83 for a gigantic distance.
Visually, the UV luminous knots are extremely faint, and
I have looked for them in other M83 images without success (detection of these objects at visible wavelengths probably requires excellent depth and also excellent angular resolution). But they "light up like candles" at <2000 Angstroms because one must assume that they contain O and B stars that are so hot that much of their emission of light is in the Far ultraviolet.
At this stage, I can't say for sure if the UV knots correspond to the blue knots that I think I see on your image.
Incidentally, very sorry that I have not answered your email about trying to detect clouds that are high above the plane of the Milky Way.
In my defense, all I can say is that I have been extremely busy with several projects, both astronomical and non-astronomical.
Best Regards,
Robert
Even just by mucking around with your .jpg, I could easily make these knots or clusters look more obvious. Some of them are very obviously resolved and extended objects, so it is highly likely that these extended knots do actually belong to M83.