If you keep total exposure short, or if the comet is a fair distance from Earth, comets don't need guiding. It's when a comet is at close approach to Earth that it's apparent motion through the sky is greatest, like 168P is presently.
At close approach a comet may show a false nucleus. If so it may be possible to guide on the false nucleus. I'm old school so I do it manually, by eye.
It's also possible to take short sub exposures and set the software to stack by aligning the comet nucleus rather than the stars. I used to use Registax to do this but I've been having trouble these days using it with large files. There may be other software that will do it but I'm still playing catchup on new techniques for doing this myself.
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