I think the biggest advantage would be seeing conditions, even a 10" scope has a theoretical max resolving power of 0.45 arcsecs, 0.3 for a 16" & 0.22 for a 20".
Even at ESO's favourite hangout in the Atacarma desert with some of the best seeing in the world it's approx 1 - 1.5 arcsecs (correct me if needed).
True that adaptive optics can help for sure, but just how effective are they? beyond the range of my knowledge.
No atmospheric extinction of UV & other wavelengths may be an advantage to some also.
As for the cosmic rays, unshielded would make for an interesting piece of modern art.

Radiation & thermal shielding would be a must have, certainly not "off the shelf" scopes these ones but the complexity of Hubble wouldn't be necessary.
Not cheap I'll admit, especially in the maintainance side of things but given 10, 20 or even 50 years it would have to become a viable enterprise.
Can you imaging what Mr Bird could do with Jupiter through one of these...