F8 will make a longer scope of course but it will also be more tolerant of focus and eyepieces. From an amateurs viewpoint it would also be easier to grind and make. A lot of smaller mirrors 4", 4.5" are made at f8, I think because it makes the scope look bigger in the shop ..
F5 seems to be the norm these days as much as easier for storage and transport as anything. F5 is also easy to make nowadays with modern factory processes. Less critical for alignment and mechanically easier for building truss type scopes, less chance of deflection.
F4 will be very critical on alignment and focussing and tough on cheaper eyepieces. Only really for experts IMHO.