I have used Matlab to do some analysis work on Ovision PEC Data. Used to use it at Uni all the time for various work. But not really for image processing in astronomy. The other two were Maple and Mathamatica.
Are you using the Image processing Toolbox? How do you find it compared to ImagesPlus. I have been using Pixinsight which i find is quiet good. It does not have a capture module though so i use nebulosity but have been thinking of getting SequenceGeneratorPro or Astroart.
I did see a thread i think maybe on Cloudynights about a chap using Matlab. I dare say it will not be so popular with Amateur Astronomers, its got a bit of a learning curve. It would be nice if someone made a Toolbox for Amateur astronomers on it. There is also I recall a free alternative to Matlab, might be nice to get a toolbox for that one.
Edit: just found this on Google, could be useful for the Metor hunters.
http://www.magnanimitas.cz/ADALTA/01.../kubickova.pdf