Excuse Me Dumb!

After all these years of only occasional sky-watching, I am still wondering is there a "best" position (rotation) of my Newtonian in it's mount? I have not found an ideal tube position, nor really an ideal height for my EQ mount. Any "rule-of-thumb", or is it simply a fact of life that you need to play with this (depending on my looking south, north, up etc!)