I have found a solution.
CCDSoft can control two detectors at once. (Note the use of the word "detectors" not "cameras").
You can set up different options for the Imager and Autoguider on the Setup Camera Setup tab. Many years of using ST7/8s I had never click on this option.
I click on on the Imager and select the St8300, then click on the Autoguider and select St-8.
In my case I need to click on settings for each camera and select the USB port the camera is on. A bit of trial an error here.
Also need to set the temperature for both cameras.
On the Take Image tab, select the camera you want to take the image, the imager of the autoguider.
Note that cameras like the ST8 that have a built in autoguider, you cannot have the ST8 main chip, the St8 autoguider and another camera working at the same as this is using 3 detectors.
From the Bisque forumns
http://www.bisque.com/sc/forums/p/2841/8777.aspx#8777
For me the solution works but does seem slighltly like a work around. Rather than having Imager, Autoguider options it should be camera 1, camera 2.
It would be nice to if software allowed for mutiple cameras and for multiple focusers.
Brendan