I look it at like this.
More lens's and optics in the path make for less light hitting your sensor. your FOV with the ED80 and 350d is perfect to capture M42,43 and running man in one hit and makes for a very pleasing shot.
If your passion is to get a bit more up and personal you will need to start changing your focal lengths/feilds of view, this is generally done with different telescopes for best results.
heres a shot with my 40d+ed 80 from december last year
http://s700.photobucket.com/albums/w...gmanandM42.png
Guided for 5x 10 min shot @ ISO 800
plus a reduction of 3 min , 1 min ,30 second shots.
hope this helps you.