Registar is a fine program but is limited by being 32 bit so it has memory limitations. It can only stack about eight 190MB tifs.
I tried the latest of version of Deep Sky Stacker and it will stack 20+ 190MB (1.6x native sensor size) tiffs and use when needed all eight (hyperthreading) processors on the Intel i920. I used Images Plus to convert raw to fit and correct for darks and flats. I then converted the unstretched fits to 16 bit tiffs. It is far better to correct for darks in the fit form as no interpolation has occurred so it is far more accurate. This of course only applies to one shot colour.
Deep Sky Stacker then only used to stack these tiffs. Image of screen shot to show the settings. It did a very good job of minimising noise with the Median Kappa-Sigma rejection. This is very cunning as it replaces the pixel values outside the set parameters with the current median value. This is far better than removing noise later by some sort of smoothing as this also loses real signal. The RGB Channels Background Calibration does a very good job of getting very close to correct colour balance.
The advantage of stacking upsized files, especially if they were dithered is that you enhance resolution. In fact it is equivalent to doubling the number of pixels on your sensor.
One problem that this causes with a 300mm optic is that at the corners now the RGB signal of each star does not exactly coincide due to slight residual CA. I just split the image into RGB tiffs and used Registar to realign them. I also used star reduction on the RGB images R 1.4, G 0.0, B 0.9. This removed the colour haloes.
Camera Canon 5DH, Canon 300mm F2.8L at f/5, Hutech LPR filter. Fridge at -10C.
Panel one RHS, Exposures 20x( 1m, 2m, 4m ) and 24x8m at 1600 ISO.
Panel two LHS. Exposures 20x( 1m, 2m, 4m ) and 22x8m at 1600 ISO.
New version large image 10MB.
http://d1355990.i49.quadrahosting.co...1/smcmos_R.jpg
Old version large image 9MB.
http://d1355990.i49.quadrahosting.co...10/sncmosd.jpg
You can see that there are far more well defined faint stars and noise is lower.
I am sure with practice that I may do better.
Bert