Howdy.
Ive always had problems with flexure induced guide error on exposures longer than a few minutes with my 10 inch F5.6 newtonian with refractor guidescope. I bought this from Alaska
http://www.aeroquest-machining.com/page9.html (its why ive not been taking images with my 10 inch for a while of late, getting it all set up and installed)
All I am waiting on now is a 1.25 inch illuminated recticle eyepiece to arrive. Tonight, I set it all up and, unable to wait, tried using my old 1 inch guider by putting bits of styrofoam round it to hold it steady in the 1.25 inch off axis guider holder. Didnt work well, it moved about, but I did get one reasonable 5 minute ISO 200 shot of Omega Centauri
Heres images of the setup I now have
http://www.users.on.net/~josiah/focuser/
see the pick off prisims here
http://www.users.on.net/~josiah/focuser/IMG_9935.jpg
Its a clever design, the whole thing can rotate 360 degrees to find guide stars. My secondary isnt big enough for the prism to get 100%, I estimate I get about 4 inches of the mirror, but I get all the focal length and no flexure induced errors.
I also got a 2 inch to T thread adaptor from Lumicon, so should get less vignetting as well. Focus point is good, I didnt need to move the primary mirror