Interesting...
Normally I would say the advantage is that you don't need a computer in the loop. That is, to use the RS232 you'd usually have:
Camera -> Computer with some guiding software -> LX RS232 port.
Where as using the guider port you would have:
Camera -> LX Autoguider port.
I wouldn't expecta device that works in one, to work correctly in the other. I would expect the two ports have a different command set. But maybe not?
If you have had it running direct to the RS232 port until now, maybe the LX200 GPS is different to my LX200 in that respect, or perhaps the Shoestring GPUSB adaptor can handle either.. I'm not sure.
Don't know if that's actually going to help you at all
Roger.