Use the ASCOM driver and most guide software can use it. PHD, MaximDL I know because I've used them both. Only one I can think of that would not work is Metaguide because it needs video instead of stills. Go with OpenPHD (free)
Then you can get back to worrying about normal astrophotography problems - weather, seeing, PE, tracking, flexure, skyglow, exposure length, processing, more aperture, etc, etc