I had a situation recently where my Primaluce Labs ESATTO Motorised Focuser would not Register as a COM Port at power up, with the USB3 cable plugged into a USB3 Port on my Pegasus Ultimate Power Box V2. I also had a 12V DC supply to the ESATTO.
If I then unplugged the cable from one USB3 Port to another adjacent USB3 Port on the UPBv2, it would then register and the COM Port appeared in Device Manager and I was good to go (indoors test due to the foul weather).
When I then plugged the ESATTO USB3 cable into Port 1 of the UPBv2 everything worked okay and the COM Port registered at power up.
So, the COM Port did not Register at power on when connected to either Port 3 or Port 4 USB3 Ports on the UPBv2, but it did Register on Port 1.
I wonder if you have something similar going on?
Cheers
Dennis