Flat fields expose the irregularities of the imaging system, ie an illuminated frame shows vignetting, dust donuts, specs, etc..
So, regularly yes. Combined no. Why? Because then you'd be adding the above where it all doesn't exist on the present exposure conditions.
Eg, if you over stretched your images; and the calibration with your current flat fields didn't remove a new dust don't you can see, then it warrants you need new flats to remove from the calibration. Unless you have some nifty processing tricks