I use 3 programs for my imaging workflow - ImagesPlus, Photoshop CS4 and (more increasingly) Nebulosity.
Still do stacking and calibration in ImagesPlus through VMware Fusion running Vista on my Intel Mac, but I find Nebulosity(Mac) very useful for aligning and scaling separate files, eg RGB image taken a month ago with a Ha image taken last week - very easy to use - Although Nebulosity seems to save files in .fit format which need to be converted to TIFFs. That can probably be changed, just haven't explored the program thoroughly yet. Seems pretty easy to use. I'm using V1.8.
Craig_L uses Nebulosity for focus/capture at the scope very effectively too.
I'm sure you'll have little trouble travelling the learning curve with this program.
Doug
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