I haven't used my DBK21 for guiding for a while, but I'm pretty sure in the dropdown I selected WDM camera instead of Imaging Source. That's using PHD.
If you're thinking of using it, have you seen/tried Metaguide? It's written as guiding software specifically for webcams. Instead of longer exposures, it uses fast frame rates of video cams like the DMK21 and shows the centroid to combat seeing. And it's free
http://www.astrogeeks.com/Bliss/MetaGuide/