I had this problem running guiding and my QHY8 until recently... a $29 PCMCIA USB controller card fixed the problem right up...
I was having problems where I could guide brilliantly in DSLR images, but as soon as I tried to image with the QHY8, the guiding would lock up.. this was because the guide cam and the QHY8 and the GPUSB were all trying to run through one controller.. now guiding/guide camera run of PCMCIA, QHY8 and motorfocus run off the PC's onboard USB controller, things are sweet!