I have not found it to be an issue myself, and have imaged the tarantula using SGP as well. It does throw the average HFR value of the frame off but at least in my experience it did not really make a difference. The detected HFR of the "Star" that clumps of nebulosity were detected as went up and down with the rest of the frame, so I found that while it would result in an bad looking final HFR compared to a more sparse star field, the actual focus run was still good.
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