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Hello V,
Full frame lenses are designed to generate a full frame image circle of approximately 43mm in diameter. The ZWO 533 will only see the central part of that with its 11.31mm X 11.31mm sensor (16mm diagonal). Any of the edge nastiness and abberations (coma, astigmatism, field curvature, ...) generated by the lens will therefore be masked somewhat., however, depending on which "manual"lenses you are referring to, more modern lenses may have higher inherent sharpness / MTF and possibly produce a sharper image, depending on your lens choices and settings. Sometimes the difference is small, sometimes it is not.
Best
JA
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