Thank you all for your various bits of advice.
Problem sorted, but not fixed.
My memory still works and it was Leon who had the same problem.
PM'ed Leon and after following his advice sorted the problem.
Leon's and my own mount are aligned as close as possible to the SP, discounting diffraction and atmospheric turbulence. So the drift of stars near the SP is very very small.
PHD, to calibrate itself, needs some movement of the selected guide star. As there is no drift or so small that PHD can't detect it it will not be able to calibrate itself.
Leons fix, which he found after trail and error, was to select different guide stars in the field until PHD calibrated. Worked for me last night whilst imaging around the LMC.
Also found out that near or around the SP, PHD will calibrate easier on a bright star. Although it will take many more steps in calibrating then when moving further away from the southpolar region.
Alexander