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I have used both and had good results with both including imaging with ha filters on OSC cameras. I think if the scope has a focal length over 1200mm and the OSC has fairly small 10 or 12 mp aps size sensor you could bin 2x2 for a luminance channel to speed things up. Of course you can do this with mono as well but normally this is done with the rgb channels. I sold my QHY8 a few years back but would like to try one of the latest cameras as I seem to produce a lot more images per month with the OSC. Another advantage is the cost filter wheel and good filters, also you can have a aps size chip instead of the 8300 size for the same money.
If you wish for full narrowband imaging then osc is the go.
Clear skies Ken.
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