A picture is worth a thousand words:
ASI183mm Pro 2.4 micron pixels on AP RHA 305 F3.8 in semi rural skies:
https://pbase.com/gregbradley/image/170949826 ASI183mm Pro
FLI Microline 16200 (6 micron pixels at a dark site):
https://pbase.com/gregbradley/image/170949827 CDK17 ML16
As you can see the 183mm image is much the same brightness despite being taken on a 305mm scope in semi rural skies versus a 435mm scope at a dark site. The CDK image should be much brighter than the 183mm but its not.
This matching pixels to optics, in my opinion, is a very limited theory and there are other factors just as important like QE, read noise, dark current, dark skies, seeing. The effects of mismatched pixels don't seem to me to be that great in reasonable seeing.
Greg.