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What Nik said. Flats are a once per session thing and if you have a setup that makes dawn or dusk flats possible, or a panel of some sort they are pretty quick and easy to get. Darks are a once a year sort of proposition where you seal it up light tight, cool it down and shoot 50 or so of each exposure, temperature, gain and offset you plan to use to generate a set of master darks that you then use until there is sign of changes sneaking in.
I am making that sound probably more complex than it needs to be. With my ASI2600 I run -10 sensor temp year round as it can maintain that year round and going deeper than that on the cooling does not make much difference, and I only ever run gain 0 or gain 100, and everything is with an offset of 50, so I really only need to shoot two sets of darks, gain 0 and gain 100, all at -10 degrees and offset 50.
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