quickly without too much thought, I think the camera on the 300mm f5 scope will have larger pixels in order to maintain the same arcsec/pixel with the longer focal length, but despite this it's performance is stated as being the same as its smaller pixel sibling, so overall, I don't think there would be any difference.
However normally, the larger pixel camera (all else being equal) would have lower noice and better efficiency, so the camera itself would be better.......
I think !!
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