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Kim, the 385 (and 224) have comparable sensitivity to the 290. The former are available in colour only, and the latter mono or colour. They're both great sensors, so it's kind of a rock and hard place situation.
It's possible you may see better colour resolution with the mono (+ filter wheel) setup because each pixel has real colour information collected, whereas with the OSC the colour is interpolated in a cluster of 4 pixels because of the Bayer array, but the (typically) high number of captured frames being stacked on top of each other really makes that a bit of a non-issue.
In practice it's really hard to objectively compare, since we'd perfect and stable conditions to be able to switch them out and run a capture.
Both 385/224 and the 290 are capable of some pretty phenomenal frame rates, it's just that with the mono you need to capture data using each filter separately. This changes the processing required. I'm not going to say one way is easier or harder, they're just different techniques.
Pushing efforts of objectivity/neutrality aside, I'd expect that the 290 mono at your native focal length would be pretty impressive all by itself as you'd get lots of light throughput that would give good signal even at high frame rates. On exceptionally good nights, you can always drop in-line a mild Barlow.
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