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Alex, is that with a 2600? I have found that the darks are quite stable, I used my first set for 12 months and only shot new ones as the old default in Astro Pixel Processor used to produce 16 bit calibration frames which could cause some posterisation. I had deleted the raw dark files so I shot a new set last month to create 32 bit master darks. If the camera is not on the scope yet you could shoot darks and bias frames before fitting it and use them for at least a year. It would only take a couple of days to shoot a good number of darks at multiple gains and exposure times and bias frames at multiple gains will not take long at all. I aim for 50 darks of each gain/exposure to make a nice smooth master dark. Just make sure any masters you create are 32 bit. That issue mostly showed up when calibrating with flats, with some difficult to correct brightening of the corners.
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