My setup is very simple nowadays.
My study is my haven and I run my audio off my desktop PC which is on all day.
Audio setup is an Asus Xonar DG sound card fed to an old Technics SA-5150 Receiver,
from there to an active Audax subwoofer and a pair of Wharfedale Valdus 200 bookshelf speakers.
Sony MDR-V6 headphones I've had for years, comfortable to wear for hours and clear crisp sound.
I don't listen to anything loud, mostly classical and mostly JS Bach!
I've moved most, 16 GB, of my music to mp3 files and I control everything from my keyboard.
Might not suit everyone, but I'm happy!
Cheers
Chris