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Yes, I have an Orion 50 mm guide scope and QHY5 (but without the helical focuser). If you're more than a couple of mm away from being in focus, the whole image will probably be black.
One way to get started is to point the guide scope at a really bright star like Sirius or Rigil Kent - just line it up roughly by looking through the scope (don't need an eyepiece).
Fit the QHY5 (I'm guessing the focus point will be somewhere close to racked in all the way), then take a really long exposure such as 10 secs. You should see a blurred outline of the star. Adjust the focus by a couple of mm in either direction. Take the 10 sec exposure again, and see if it's closer/further out of focus.
As you get nearer to the focus point, the star will become brighter and so you can reduce the exposure. Keep tweaking until you're spot on. At this point, I usually like to get a pencil and draw lightly on the tube to mark where the focus point roughly is for next time.
Hope this helps!
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