Noiseware professional is an awesome photoshop plugin. I used since day one. John Glossop put me onto it 6yrs ago. I have also noise ninja and neat image but they're not as good as Noiseware. But the best targeted noise reduction I've seen by far and that works when all other fails is
Startools. It works in the 16bit environment of the FIT files and is integrated in the workflow (i.e. sharpening, deconv, strectching). It yelds the best results. Haven't seen anything that comes even close to it. (yet).