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As I go I find that noise reduction levels should be different depending how you're going to present your pictures.
If you're going to show a close up close to 1:1 or 80%-90% then you'll need some kind of clever noise reduction algorithm to make your image smooth while keeping deconv details and sharpening.
If you're ultimately going to do a mosaic and end up with a 50% or even 20% display then it's best to not noise reduce as your contrast will be enhanced anyway when you 'bin' so to speak the whole picture and the noise won't be noticeable.
I often found that large mosaic I stitched at 1:1 taking care of noise at that image scale looked lifeless and 'faded' when reduced. So I often ended up doing two versions. One with noise reduction and the other without for smaller display size.
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