Hi Matt,
in my opinion the first of the 4 images looks best, the large single image whilst the noise reduction is effective it seems as though some of the stars on the top right half are suffering chromatic aberration.
I use the "Noise Reduction on long exposures" setting on my camera, then in Photoshop RAW I apply "lens correction" and "luminance" approx 20%. Afterwards if image still appears grainy I will sharpen and guassian blur.
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