Manual tracking would be possible, however I tracked the Hubble on dusk one night from the west/northwest to the north/northeast for about a minute or so with a ED80 (25mm eyepiece) on a Losmandy GM8. Wasn't easy I'll tell you. Wouldn't have been too bad if it I only had to make Dec changes or RA changes. But having to do both and keep it in the eyepiece at the same time was a real challenge. It's amazing how fast that thing moves when you're trying to track it in an eye piece. With practice you would probably have no trouble, but I'd hate to try and track it manually and image it at the same time.
Btw, I didn't see any detail just a bright moving "star" It as a hoot though
I know the ISS isn't as far as the Hubble but it's apparent rate of motion is faster.