If you can handle the extra weight and size of the 10" and budget is of no concern than I can't imagine you'd ever regret the choice.
I recently bought an 8" Dob and it's bloody brilliant. Just small enough that I can manhandle it in and out of the house, the W.A.F. (Wife Acceptance Factor) when it is inside the house under a sheet (dust cover) is high as well and above all else it is a magnificent bit of gear to use.
In saying that, I looked at 10" and 12" when I was buying and if I had the budget I probably would have gone those extra few inches.
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