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I just had a quick play with the dropbox file in PixInsight.
Workflow:
Crop
DBE
Background Neutralisation
Colour Correction (using NGC253 itself as the white reference, with structure detection unchecked)
a quick Histogram stretch
HDR Multiscale Transform (4 layers, deringing enabled, no lightness mask)
Denoise - SCNR followed by ACDNR
Curve adjustment - saturation and luminance
I'm sure others can do better - i'm still learning the ropes with PixInsight myself.
btw I noticed after i finished all that there are some hot pixels in the image. running a cosmetic correction didn't seem to work for me to get rid of them, so you probably needed to do that back during the calibration and stacking step.
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