That setting in the Telescope tab doesn't affect guiding AFAIK. It's used for auto centering.
I recently tried CCD Commander, CCDAP and ACP. I had the same problem you did with all of them. As well as turning off Pier Flip and Auto Pier flip in the Guide tab I found it helped to always calibrate with the scope pointing East and not far from 0 Dec. I did manage to get it working in every case but it sometimes took a couple of attempts. I don't think I ever managed to get guiding to work with CCDAP choosing the guide star - but it did work with Maxim choosing the star.
Good luck!
Cheers,
Rick.
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