I've had my 10" Dob for about 10 years now and I have washed the primary mirror 5 times and the secondary mirror twice. If I see dust on the primary and it doesn't affect the image quality, i'll wait 12 months before I'd think about washing it. The amount of dust covering a primary mirror wouldn't even cover the centreing ring in the middle.
I agree with Michael...as long as you're gentle and methodical, no worries!
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