I do have friends who have upgraded to SSD's and have seen very noticeable improvement.
Another friend upgraded the HDD of 6 Mac's of all his family and friends and they're all heaps faster. I'm sure others have done the same here.
Biggest factor with hard disks are seek times, if there is heavy paging or a lot of disk I/O, 7200rpm or higher and hard disks with low seek times make a huge difference, so SSD's with much lower seek times would make application response faster.
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