Hi,
I'm certainly with Jarrod on MalwareBytes (MBam), based on experience. I was using MSE and nonetheless my PC contracted a real bugger of an infection (from visiting Internet sites on crocheting

), a rootkit which was the devil to get rid of. This turned out to be a brand new nasty which was not yet in the MSE database (that however is common enough).
MSE could not even see it directly, just the fallout from it (files it altered), so I got MBam for $25, perpetual licence, one-time payment. This entitled me to open with them a "ticket" on my PC infection, and then, prolonged advice from one of their experts, named Tom Mercado. He seemed to have seen everything before, and directed me to use one industry virus killer after another from various sources on the Net. Soon the infection was gone.
The only other difference between the freeware version (no support) and the paid version of MBam is that the paid version (MBam Pro) is resident and starts up each boot on your PC, whereas the freeware resides in the Cloud and has to be called manually whenever you want it to run.
I have no connection with them except that they saved me
Cheers