Depends what Crayford you have in mind. You will find there is actually a threaded end cap that the Unitron focuser is screwed into. Feathertouch actually make an adapter that will go into this thread.
I bought a JMI event horizon for an SCT and got a local machinist to make an adapter. If you're interested, I'll put up some pics.
As to your original question, I use a blob of grease to hold a non-captive nut in place. Once the screw nips up it shoukdn't move, but if you unscrew the focuser first you will be able to get in there with needlenose pliers.
cheers,
Andrew
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