Nothing is foolproof so it will come down to a risk analysis - what level of risk are you comfortable with? I leave my Meade 14 on its Meade mount to run all night on it's own slewing between multiple targets and imaging each target is sets (ie Target 1, then 2, then 3, then 4 then back to 1 etc all night). I have been doing this every clear night for a decade (around 8000hrs of operation) and have had 2 mishaps (pointed below the observatory limits) but no hardware damage or even contact.
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