Not sure whether you have already tried this, but try switching USB cables - I have had several flaky ones that will work intermittently, and even one that would work with everything BUT my QHY5. Go figure. Is it connected through a hub or anything, or just straight into the PC?
Basically suspect everything, then if no luck try the camera on another PC, reload drivers, you can even try restoring windows to a date that you know was good (just be careful with any software you have updated/loaded recently as you will lose them)
Adam
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