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The other important thing is for the flat to be only exposed within the linear part of your CCD. If you have an antiblooming CCD then it will start to have a non linear response somewhere over 1/2 the full wells. Keeping the max exposure to 1/2 the full wells is a safe way of preventing this. There is an advantage to having the brightest exposure you can as it reduces noise but you must keep in the linear part of the CCD- a fine balance needs to be made.
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