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You will find life is much simpler if you always plug your USB to serial converters in exactly the same port.
Not just the same port in the computer. If you are using an external hub, the hub has to be in the same PC port, and the converter in the same port in the hub.
Label everything is the way to go.
My solution has been disputed a few times here, but works for me.
Make sure you have driver installers for all your devices.
Unplug all your USB to serial devices.
Right click "my computer". Select "manage".
Select "device manager".
"view" menu -> "show hidden devices"
Expand" ports (com & lpt)"
Right click each USB to serial entry, and "uninstall" from the menu.
Reboot.
Starting with any external hubs, decide where you want each cable to go every time you will plug it in.
Plug the hubs in one by one.
Plug the other cables in one by one.
Windoze should reinstall all the drivers, and the USB to serial COM ports should start numbering from close to zero.
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