We all feel your pain Houghy!
I've had the dog come in and upset a couple of cables and things stopped working.
Guess you can't kick your daughter ... !
I'd like a dollar for the amount of computers I've rebuilt/ gone through, upgraded, reformatted over the past 9 years out in the observatory when things go crap..... and lots of times it's been after the hour of midnight and not unusual to have to work the next day... lucky I always have spare m/b's, HDDs, ram, psu's and lots of patience.
Think H is on the right track.
Some of those hubs can cause a lot of grief and lock up the ports...
Some times it can be PID devices that block other usb devices.. can be a real pain.
You'll get there I'm sure... if it was working once, then you should be able to repeat it....