Dean, with your laser in and switched on and the mirrors adjusted so the beam is going where it should, move your scope from horizon to zenith and see if the laser spot moves much on primary mirror or on the return target on the laser. This can be useful to see if you have any movement or flexure. Don't be surprised to see a mm or two of movement. No movement would be great. If there is much movement, then try to work out why and fix it. The primary mirror cell sagging a bit on its support springs is a common cause, if that is the way it is mounted. One thing to do if there is movement is to choose where you will be observing - say an elevation of 60 deg or so - and tweak the collimation to spot on at that elevation.
By the way, after I have done a reflector with the laser collimator, I find the cheshire agrees very closely.
Tell us how it goes.