What capture software are you using? CCDsoft stretches the downloaded image so even a faint galaxy will show in a 4-10 second image. If it won't show even with that then it would probably not show in a normal long exposure either (say 2-3 hours total).
One exception is the Vela Supernova Remnant which hardly shows anything under a 1 minute exposure unless you are using O111 filters.
I sometimes open up a downloaded 10 minute test frame in CCDstack to check it out before committing to a 5 hour run. Especially to check focus and guiding errors.
Greg.
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